Question:
All of the following statements about phenytoin are true, except:
All of the following statements about phenytoin are true, except:
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Phenytoin affects blood sugar, but in which direction does it push insulin?
Updated On: Jun 24, 2026
- Follows saturation kinetics
- Is teratogenic
- Is highly protein bound
- Stimulates insulin secretion
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The Correct Option is D
Solution and Explanation
Step 1: This is a negative-stem question, so find the FALSE statement.
Step 2: Check option A. Phenytoin shows saturation (zero-order) kinetics within the therapeutic range, meaning once its metabolizing enzymes are saturated, a small dose rise causes a large jump in plasma level. This is TRUE.
Step 3: Check option B. Phenytoin is teratogenic and causes fetal hydantoin syndrome. This is TRUE.
Step 4: Check option C. Phenytoin is about 90 percent bound to plasma albumin, so it is highly protein bound. This is TRUE.
Step 5: Check option D. Phenytoin actually INHIBITS insulin release and can cause hyperglycemia, the opposite of stimulating insulin secretion. So this statement is FALSE.
Step 6: Since the question wants the false statement, option D is the answer.
Answer: Option D.
Step 2: Check option A. Phenytoin shows saturation (zero-order) kinetics within the therapeutic range, meaning once its metabolizing enzymes are saturated, a small dose rise causes a large jump in plasma level. This is TRUE.
Step 3: Check option B. Phenytoin is teratogenic and causes fetal hydantoin syndrome. This is TRUE.
Step 4: Check option C. Phenytoin is about 90 percent bound to plasma albumin, so it is highly protein bound. This is TRUE.
Step 5: Check option D. Phenytoin actually INHIBITS insulin release and can cause hyperglycemia, the opposite of stimulating insulin secretion. So this statement is FALSE.
Step 6: Since the question wants the false statement, option D is the answer.
Answer: Option D.
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