Question:
All of the following agents are used for prophylaxis of migraine, except:
All of the following agents are used for prophylaxis of migraine, except:
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One option is purely an absence-seizure drug.
Updated On: Jun 24, 2026
- Propranolol
- Valproate
- Topiramate
- Ethosuximide
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The Correct Option is D
Solution and Explanation
Step 1: Migraine prophylaxis means daily drugs taken to reduce attack frequency, not to abort an attack.
Step 2: Propranolol, a non-selective beta blocker, is a first-line and most commonly used prophylactic agent for migraine. So option A is used.
Step 3: Sodium valproate is an established prophylactic antiepileptic for migraine. So option B is used.
Step 4: Topiramate is another antiepileptic with proven efficacy in migraine prophylaxis. So option C is used.
Step 5: Ethosuximide acts on T-type calcium channels and is used ONLY for absence (petit mal) seizures. It has no role in migraine prophylaxis. So option D is the exception.
Conclusion: The drug not used for migraine prophylaxis is option D, ethosuximide.
Step 2: Propranolol, a non-selective beta blocker, is a first-line and most commonly used prophylactic agent for migraine. So option A is used.
Step 3: Sodium valproate is an established prophylactic antiepileptic for migraine. So option B is used.
Step 4: Topiramate is another antiepileptic with proven efficacy in migraine prophylaxis. So option C is used.
Step 5: Ethosuximide acts on T-type calcium channels and is used ONLY for absence (petit mal) seizures. It has no role in migraine prophylaxis. So option D is the exception.
Conclusion: The drug not used for migraine prophylaxis is option D, ethosuximide.
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