Question:
All are true about Aprepitant except?
All are true about Aprepitant except?
Show Hint
Antiemetics block substance P; is aprepitant really an agonist?
Updated On: Jun 24, 2026
- Agonist at NK1
- Crosses blood brain barrier
- Ameliorates nausea and vomiting of chemotherapy
- Metabolized by CYP3A4
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
Step 1: Identify the drug. Aprepitant is an antiemetic used to prevent chemotherapy-induced and postoperative nausea and vomiting.
Step 2: Recall its true mechanism. Aprepitant is a neurokinin-1 (NK1) receptor antagonist; it blocks the action of substance P in the vomiting centre. Therefore calling it an NK1 agonist is false.
Step 3: Verify the remaining statements. It is lipophilic and crosses the blood brain barrier to act centrally (B true). It clearly reduces chemotherapy-related nausea and vomiting, especially the delayed phase (C true). It is a substrate of CYP3A4 and also inhibits CYP3A4, leading to drug interactions (D true).
Step 4: Select the exception. Since the stem asks for the false statement, the NK1 agonist claim is the exception.
Answer: Option A, Agonist at NK1.
Step 2: Recall its true mechanism. Aprepitant is a neurokinin-1 (NK1) receptor antagonist; it blocks the action of substance P in the vomiting centre. Therefore calling it an NK1 agonist is false.
Step 3: Verify the remaining statements. It is lipophilic and crosses the blood brain barrier to act centrally (B true). It clearly reduces chemotherapy-related nausea and vomiting, especially the delayed phase (C true). It is a substrate of CYP3A4 and also inhibits CYP3A4, leading to drug interactions (D true).
Step 4: Select the exception. Since the stem asks for the false statement, the NK1 agonist claim is the exception.
Answer: Option A, Agonist at NK1.
Was this answer helpful?
0
0
Top NEET PG Pharmacology Questions
- A bronchial asthma patient on inhalational steroids presented with white patchy lesions on the tongue and buccal mucosa. What is the drug that can be used to treat this condition?
- A pregnant woman with a history of bronchial asthma is in the third stage of labor. Which drugs should be avoided in managing postpartum hemorrhage in this mother?
- Name the drug that acts on both the marked areas.
- A patient with a previous history of myocardial infarction and ventricular arrhythmia is ontreatment for a few months. He developed fatigue, dyspnea, and weight gain. He had also developed pulmonary fibrosis. Which of the following drugs is responsible for the side effects mentioned above?
- A young female comes to the emergency department after consuming 100 aspirin tablets.What should be the next step in management?
View More Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions