Question

After kidney transplantation, infection with which organism is most likely to occur?

• A. CMV
• B. Klebsiella
• C. Streptococcus
• D. Staphylococcus

Hint:

Think latent virus reactivating under T-cell suppression.

Answer 1

The Correct Option is A

Step 1: After renal transplantation patients receive intense immunosuppression, which most strongly impairs T-cell control of viruses. Step 2: Cytomegalovirus (CMV) is the single most common and clinically important viral infection in this setting, typically appearing in the first few months. Step 3: CMV disease presents as fever (the most common feature), leukopenia, hepatosplenomegaly, myalgia, and arthralgia, and can also cause organ-specific disease and allograft dysfunction - so option a is correct. Step 4: Klebsiella, Streptococcus, and Staphylococcus do cause post-transplant infections but are not the characteristic, most likely opportunistic pathogen highlighted for the transplant immunosuppressed host, so b, c, and d are wrong.