Question:
About diabetes insipidus, all of the following are true EXCEPT:
About diabetes insipidus, all of the following are true EXCEPT:
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Like cortisol, thyroid hormone is permissive for free-water excretion.
Updated On: Jun 24, 2026
- The water deprivation test is diagnostic
- Before doing the test, hypoadrenalism (cortisol deficiency) should first be corrected
- Hypothyroidism does not affect the diagnostic test
- Pre-test serum osmolality of 288 mOsm/kg is in the normal range
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The Correct Option is C
Solution and Explanation
Step 1: Note this is a negative (true-except) question, so the correct choice is the false statement.
Step 2: Evaluate the true statements. The water deprivation test (with desmopressin response) is the standard diagnostic test for diabetes insipidus, so option A is true. Coexisting adrenal insufficiency must be corrected before the test, because cortisol is required for normal free-water excretion and uncorrected hypoadrenalism can mask DI, so option B is true. A serum osmolality of 288 mOsm/kg lies within the normal reference range (about 275 to 295 mOsm/kg), so option D is true.
Step 3: Identify the false statement. Thyroid hormone is also permissive for renal free-water clearance, and hypothyroidism can impair free-water excretion and thereby alter the water deprivation test result. Therefore the claim that hypothyroidism does not affect the diagnostic test is false.
Step 4: Conclusion. The exception (false statement) is option C.
The medically correct and printed answer is option 3.
Step 2: Evaluate the true statements. The water deprivation test (with desmopressin response) is the standard diagnostic test for diabetes insipidus, so option A is true. Coexisting adrenal insufficiency must be corrected before the test, because cortisol is required for normal free-water excretion and uncorrected hypoadrenalism can mask DI, so option B is true. A serum osmolality of 288 mOsm/kg lies within the normal reference range (about 275 to 295 mOsm/kg), so option D is true.
Step 3: Identify the false statement. Thyroid hormone is also permissive for renal free-water clearance, and hypothyroidism can impair free-water excretion and thereby alter the water deprivation test result. Therefore the claim that hypothyroidism does not affect the diagnostic test is false.
Step 4: Conclusion. The exception (false statement) is option C.
The medically correct and printed answer is option 3.
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