Question:
A solitary lytic bone lesion can be seen in which of the following conditions?
A solitary lytic bone lesion can be seen in which of the following conditions?
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Think FOG MACHINES; the M is myeloma, the classic lytic lesion.
Updated On: Jun 23, 2026
- Atherosclerosis
- Multiple myeloma
- Mitral stenosis
- Osteoblast
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: The differential for a lytic (bone-destroying) lesion is captured by the mnemonic FOG MACHINES: Fibrous dysplasia or fibrous cortical defect, Osteoblastoma, Giant cell tumour, Metastases and Myeloma, Aneurysmal bone cyst, Chondroblastoma or chondromyxoid fibroma, Hyperparathyroidism brown tumour, Infection, Non-ossifying fibroma, Enchondroma or eosinophilic granuloma, and Simple bone cyst.
Step 2: Multiple myeloma is a classic cause of lytic lesions and the solitary form, a plasmacytoma, presents as a single lytic bone lesion. So it fits the question directly.
Step 3: The other choices are not bone-lytic processes. Atherosclerosis and mitral stenosis are cardiovascular conditions, and osteoblast is a bone-forming cell rather than a disease that destroys bone.
Step 4: Hence the correct answer is multiple myeloma, option b.
Step 2: Multiple myeloma is a classic cause of lytic lesions and the solitary form, a plasmacytoma, presents as a single lytic bone lesion. So it fits the question directly.
Step 3: The other choices are not bone-lytic processes. Atherosclerosis and mitral stenosis are cardiovascular conditions, and osteoblast is a bone-forming cell rather than a disease that destroys bone.
Step 4: Hence the correct answer is multiple myeloma, option b.
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