Question:
A patient with mediastinal mass was diagnosed with red cell aplasia. What is the probable cause?
A patient with mediastinal mass was diagnosed with red cell aplasia. What is the probable cause?
Updated On: Jul 16, 2025
- Bronchogenic carcinoma
- NHL
- Thymic neoplasia
- T cell ALL
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The Correct Option is C
Solution and Explanation
The presence of a mediastinal mass in conjunction with red cell aplasia suggests clinical correlation with a condition known as pure red cell aplasia. This condition often occurs due to the presence of a thymoma, a type of tumor associated with thymic neoplasia. Thymomas are commonly located in the anterior mediastinum, which aligns with the symptoms of a mediastinal mass in the patient.
| Condition | Association |
|---|---|
| Thymic neoplasia (Thymoma) | Pure red cell aplasia |
| Bronchogenic carcinoma | Not typically associated with red cell aplasia |
| NHL (Non-Hodgkin Lymphoma) | Not typically associated with red cell aplasia |
| T cell ALL (Acute Lymphoblastic Leukemia) | Not typically associated with red cell aplasia |
Thus, in a patient diagnosed with red cell aplasia and presenting with a mediastinal mass, thymic neoplasia is the most probable cause. Thymomas can disrupt normal erythropoiesis leading to the observed aplasia.
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