Question:
A drug acting on potassium (K+) channels includes which of the following?
A drug acting on potassium (K+) channels includes which of the following?
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Find the antianginal K+ channel opener with an NO-donor action.
Updated On: Jun 23, 2026
- Spironolactone
- Amiloride
- Nicorandil
- Methyldopa
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The Correct Option is C
Solution and Explanation
Step 1: The question wants a drug whose primary mechanism involves potassium channels.
Step 2: Nicorandil is a potassium channel opener. By activating myocardial ATP-sensitive K+ channels it produces ischemic preconditioning and coronary vasodilation, and it additionally releases nitric oxide. It is used in angina.
Step 3: The distractors act elsewhere. Spironolactone is an aldosterone (mineralocorticoid receptor) antagonist; amiloride blocks epithelial sodium (ENaC) channels; methyldopa is a central alpha-2 agonist antihypertensive. None primarily target K+ channels.
Step 4: Therefore the K+ channel drug is Nicorandil.
Step 2: Nicorandil is a potassium channel opener. By activating myocardial ATP-sensitive K+ channels it produces ischemic preconditioning and coronary vasodilation, and it additionally releases nitric oxide. It is used in angina.
Step 3: The distractors act elsewhere. Spironolactone is an aldosterone (mineralocorticoid receptor) antagonist; amiloride blocks epithelial sodium (ENaC) channels; methyldopa is a central alpha-2 agonist antihypertensive. None primarily target K+ channels.
Step 4: Therefore the K+ channel drug is Nicorandil.
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