Question:

A diabetic patient on insulin glargine and metformin has persistent hyperglycemia with HbA1c 8.3% and signs of heart failure. Which is the most appropriate medication to add next?

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Diabetes with heart failure: prefer SGLT2 inhibitors like empagliflozin.
Updated On: May 14, 2026
  • Sitagliptin
  • Pioglitazone
  • Empagliflozin
  • Gliclazide
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The Correct Option is C

Solution and Explanation

Concept: SGLT2 inhibitors such as empagliflozin are beneficial in type 2 diabetes with heart failure because they reduce heart failure hospitalization and provide cardiovascular benefit.

Step 1:
Identify comorbidity.
The patient has diabetes with signs of: \[ \text{Heart failure} \]

Step 2:
Choose drug with heart failure benefit.
Empagliflozin is an SGLT2 inhibitor with proven heart failure benefit.

Step 3:
Avoid harmful option.
Pioglitazone can worsen fluid retention and heart failure. Therefore, the best drug is: \[ \text{Empagliflozin} \]
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