Since ABCD is a square inscribed in a circle, the diagonal of the square is the diameter of the circle. Let the radius of the circle be \( r = 8 \, \text{cm} \). Then, the diagonal of the square is:
\[
\text{Diagonal of square} = 2r = 2 \times 8 = 16 \, \text{cm}.
\]
Let the side length of the square be \( s \). Using the Pythagorean theorem for the square, we have:
\[
\text{Diagonal}^2 = s^2 + s^2 = 2s^2.
\]
Thus:
\[
16^2 = 2s^2 \quad \Rightarrow \quad 256 = 2s^2 \quad \Rightarrow \quad s^2 = \frac{256}{2} = 128.
\]
Therefore, the area of the square is \( \boxed{100 \, \text{cm}^2} \).