Let the center of the circle be \( O \), and the radius of the circle be \( r = 8 \) cm. Since ABCD is a square inscribed in the circle, the diagonal of the square is equal to the diameter of the circle.
The diagonal of the square \( d = 2r = 2 \times 8 = 16 \) cm.
For a square, the relation between the side \( s \) and the diagonal \( d \) is:
\[
d = s \sqrt{2}.
\]
Substituting \( d = 16 \):
\[
16 = s \sqrt{2}.
\]
Solving for \( s \):
\[
s = \frac{16}{\sqrt{2}} = 16 \times \frac{\sqrt{2}}{2} = 8\sqrt{2} \, \text{cm}.
\]
The area of the square is:
\[
\text{Area} = s^2 = (8\sqrt{2})^2 = 64 \times 2 = 128 \, \text{cm}^2.
\]
Thus, the correct answer is:
\[
\boxed{100 \, \text{cm}^2}.
\]