Question:

A 50-year-old patient presents with a slowly growing, painless neck mass at the angle of the mandible. “Lyre's sign” is observed. What is the most likely diagnosis?

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Neck mass at carotid bifurcation with Lyre's sign = carotid body tumor.
Updated On: May 14, 2026
  • Thyroid nodule
  • Lymphadenopathy
  • Carotid body tumor
  • Branchial cyst
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The Correct Option is C

Solution and Explanation

Concept: Carotid body tumor is a paraganglioma located at the carotid bifurcation. On angiography, it splays the internal and external carotid arteries, producing the classic Lyre's sign.

Step 1:
Identify the mass location.
A painless neck mass near the angle of the mandible suggests a lesion near the carotid bifurcation.

Step 2:
Use the specific sign.
Lyre's sign is due to splaying of carotid arteries.

Step 3:
Select the diagnosis.
The condition classically associated with Lyre's sign is: \[ \text{Carotid body tumor} \] Therefore, the correct answer is Carotid body tumor.
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