Question

A 45-year-old patient presents with a chronic granulomatous skin lesion. What is the most confirmatory diagnostic test for this condition?

• A. PCR (Polymerase Chain Reaction)
• B. Slit skin smear
• C. Mantoux test
• D. Skin biopsy with histopathology

Hint:

PCR is useful for confirmatory diagnosis because it detects pathogen-specific genetic material.

Answer 1

The Correct Option is A

Concept: For chronic granulomatous skin infections, molecular diagnosis by PCR can provide high specificity and confirmation by detecting organism DNA.

Step 1: Identify lesion type.
The lesion is chronic and granulomatous, suggesting an infective granulomatous dermatosis.

Step 2: Need for confirmatory test.
Clinical features and routine microscopy may suggest diagnosis, but confirmatory diagnosis requires detecting the causative organism.

Step 3: Choose confirmatory test.
The most confirmatory test among the options is: \[ \text{PCR} \]