Question:
A 40-year-old male patient presents with GERD. Which of the following drugs helps in contraction of the lower esophageal sphincter and increases gastric emptying?
A 40-year-old male patient presents with GERD. Which of the following drugs helps in contraction of the lower esophageal sphincter and increases gastric emptying?
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GERD with need for prokinetic action: metoclopramide increases LES tone and gastric emptying.
Updated On: May 14, 2026
- Metoclopramide
- Pantoprazole
- Vonoprazan
- Sodium alginate
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The Correct Option is A
Solution and Explanation
Concept:
Metoclopramide is a prokinetic drug. It increases lower esophageal sphincter tone and enhances gastric emptying.
Step 1: Identify the required action.
The question asks for a drug that: \[ \text{Increases LES contraction + increases gastric emptying} \]
Step 2: Recall prokinetic drug.
Metoclopramide acts as a dopamine D2 antagonist and has prokinetic effects.
Step 3: Differentiate from acid suppressants.
Pantoprazole and vonoprazan reduce acid secretion but do not primarily increase LES tone or gastric emptying. Therefore, the correct answer is Metoclopramide.
Step 1: Identify the required action.
The question asks for a drug that: \[ \text{Increases LES contraction + increases gastric emptying} \]
Step 2: Recall prokinetic drug.
Metoclopramide acts as a dopamine D2 antagonist and has prokinetic effects.
Step 3: Differentiate from acid suppressants.
Pantoprazole and vonoprazan reduce acid secretion but do not primarily increase LES tone or gastric emptying. Therefore, the correct answer is Metoclopramide.
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