Question:
A 35-year-old man diagnosed with pheochromocytoma is scheduled for surgery. Which medication should be given as preoperative preparation?
A 35-year-old man diagnosed with pheochromocytoma is scheduled for surgery. Which medication should be given as preoperative preparation?
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Pheochromocytoma surgery preparation: alpha blockade first with phenoxybenzamine, then beta blockade if needed.
Updated On: May 14, 2026
- Clonidine
- Phenoxybenzamine
- Esmolol
- Aspirin
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The Correct Option is B
Solution and Explanation
Concept:
Pheochromocytoma is a catecholamine-secreting tumor. Preoperative preparation requires alpha blockade before surgery to prevent hypertensive crisis.
Step 1: Identify the condition.
Pheochromocytoma secretes catecholamines, causing episodic hypertension, headache, palpitations, and sweating.
Step 2: Recall preoperative preparation.
Before surgery, alpha blockade is given first. The classical drug is: \[ \text{Phenoxybenzamine} \]
Step 3: Avoid beta blocker first.
Beta blockers should not be given before alpha blockade because unopposed alpha stimulation can worsen hypertension. Therefore, the correct answer is Phenoxybenzamine.
Step 1: Identify the condition.
Pheochromocytoma secretes catecholamines, causing episodic hypertension, headache, palpitations, and sweating.
Step 2: Recall preoperative preparation.
Before surgery, alpha blockade is given first. The classical drug is: \[ \text{Phenoxybenzamine} \]
Step 3: Avoid beta blocker first.
Beta blockers should not be given before alpha blockade because unopposed alpha stimulation can worsen hypertension. Therefore, the correct answer is Phenoxybenzamine.
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