Question:

Which of the following is the drug of choice for cyclosporiasis?

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Coccidian gut protozoa (Cyclospora/Isospora) respond to co-trimoxazole.
Updated On: Jun 23, 2026
  • Trimethoprim-sulfamethoxazole combination
  • Paromomycin
  • Metronidazole
  • Cyclosporine
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The Correct Option is A

Solution and Explanation

Step 1: Cyclosporiasis is an intestinal protozoal infection caused by Cyclospora cayetanensis, presenting with watery diarrhea, especially in travelers and immunocompromised patients.
Step 2: The drug of choice is the combination of trimethoprim with sulfamethoxazole (co-trimoxazole). The same combination is also first-line for the closely related Isospora (Cystoisospora) infection.
Step 3: The distractors do not cover Cyclospora: paromomycin is used for cryptosporidiosis and amoebiasis, metronidazole treats giardiasis and amoebiasis, and cyclosporine is an immunosuppressant (note the deliberately similar name, not an antimicrobial).
Step 4: Therefore the correct answer is the trimethoprim-sulfamethoxazole combination.
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