Step 1: Cyclosporiasis is an intestinal protozoal infection caused by Cyclospora cayetanensis, presenting with watery diarrhea, especially in travelers and immunocompromised patients.
Step 2: The drug of choice is the combination of trimethoprim with sulfamethoxazole (co-trimoxazole). The same combination is also first-line for the closely related Isospora (Cystoisospora) infection.
Step 3: The distractors do not cover Cyclospora: paromomycin is used for cryptosporidiosis and amoebiasis, metronidazole treats giardiasis and amoebiasis, and cyclosporine is an immunosuppressant (note the deliberately similar name, not an antimicrobial).
Step 4: Therefore the correct answer is the trimethoprim-sulfamethoxazole combination.