Question:
Which of the following drugs is NOT used for the medical treatment of diabetic retinopathy?
Which of the following drugs is NOT used for the medical treatment of diabetic retinopathy?
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One of these is a breast-cancer anti-oestrogen, not a retinal protectant.
Updated On: Jun 24, 2026
- Tamoxifen
- Benfotiamine
- Pyridazinones
- Ruboxistaurin
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The Correct Option is A
Solution and Explanation
Step 1: Recall the pharmacological strategies aimed at diabetic retinopathy. They target the biochemical pathways of hyperglycaemic damage, including the polyol pathway, advanced glycation end products, protein kinase C activation and oxidative stress.
Step 2: Place each correct option in its pathway. Benfotiamine, a lipid-soluble thiamine derivative, blocks several hyperglycaemia-driven pathways and reduces advanced glycation end products. Ruboxistaurin is a selective protein kinase C beta inhibitor studied to slow visual loss in diabetic retinopathy. Pyridazinones have been investigated as agents that improve retinal microvascular function.
Step 3: Examine the odd one out. Tamoxifen is a selective oestrogen receptor modulator used in breast cancer. It has no role in diabetic retinopathy and is in fact itself a recognised cause of drug-induced retinopathy with crystalline deposits.
Step 4: Conclude. The drug NOT used for diabetic retinopathy is tamoxifen.
Step 2: Place each correct option in its pathway. Benfotiamine, a lipid-soluble thiamine derivative, blocks several hyperglycaemia-driven pathways and reduces advanced glycation end products. Ruboxistaurin is a selective protein kinase C beta inhibitor studied to slow visual loss in diabetic retinopathy. Pyridazinones have been investigated as agents that improve retinal microvascular function.
Step 3: Examine the odd one out. Tamoxifen is a selective oestrogen receptor modulator used in breast cancer. It has no role in diabetic retinopathy and is in fact itself a recognised cause of drug-induced retinopathy with crystalline deposits.
Step 4: Conclude. The drug NOT used for diabetic retinopathy is tamoxifen.
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