Question:
Which of the following drugs acts as a neurokinin-1 (NK1) receptor antagonist to prevent chemotherapy-induced vomiting?
Which of the following drugs acts as a neurokinin-1 (NK1) receptor antagonist to prevent chemotherapy-induced vomiting?
Show Hint
Chemotherapy-induced nausea and vomiting (CINV) is controlled by drugs acting on several receptor systems. Substance P, acting on neurokinin-1 (NK1) receptors, is a key mediator of the delayed phase of vomiting.
Updated On: Jun 24, 2026
- Ondansetron
- Aprepitant
- Dronabinol
- Metoclopramide
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Concept:
Chemotherapy-induced nausea and vomiting (CINV) is controlled by drugs acting on several receptor systems. Substance P, acting on neurokinin-1 (NK1) receptors, is a key mediator of the delayed phase of vomiting.
How it works: Aprepitant is a selective NK1 receptor antagonist. By blocking substance P at NK1 receptors in the vomiting centre, it prevents both acute and delayed CINV, and is usually combined with a 5-HT3 blocker and a corticosteroid.
Why the other choices are wrong: Ondansetron is a 5-HT3 antagonist. Dronabinol is a cannabinoid. Metoclopramide is mainly a dopamine D2 antagonist (with some 5-HT3 effect). None of these blocks NK1 receptors.
Answer: Option (2) — Aprepitant is the NK1 receptor antagonist. (2)
Chemotherapy-induced nausea and vomiting (CINV) is controlled by drugs acting on several receptor systems. Substance P, acting on neurokinin-1 (NK1) receptors, is a key mediator of the delayed phase of vomiting.
How it works: Aprepitant is a selective NK1 receptor antagonist. By blocking substance P at NK1 receptors in the vomiting centre, it prevents both acute and delayed CINV, and is usually combined with a 5-HT3 blocker and a corticosteroid.
Why the other choices are wrong: Ondansetron is a 5-HT3 antagonist. Dronabinol is a cannabinoid. Metoclopramide is mainly a dopamine D2 antagonist (with some 5-HT3 effect). None of these blocks NK1 receptors.
Answer: Option (2) — Aprepitant is the NK1 receptor antagonist. (2)
Was this answer helpful?
0
0
Top TS PGECET Pharmacy Questions
- Increase in the solubility of the aqueous systems by adding large amount of additives is known as.........
- Clark's formula………
- One of the following is used as a key ingredient in hair conditioning product
- Empty capsule has moisture content in the range of ………
- Aerosol container must withstand pressures as high as 140–180 psi at ………
View More Questions
Top TS PGECET Pharmacology Questions
- Clark's formula………
- What is the final product of purine metabolism in humans?
- In type 2 diabetes mellitus, pancreatic beta cells initially respond to insulin resistance by………
- Underlying mechanism for variant angina is………
- The physiologic effect of PGF2-ALFA
View More Questions
Top TS PGECET Questions
- If \( P = \begin{pmatrix} 1 & 1 & 1 \\ 0 & 1 & 2 \\ 0 & 0 & 1 \end{pmatrix} \) is the modal matrix of \( A = \begin{pmatrix} 1 & 1 & 0 \\ 0 & 2 & 2 \\ 0 & 0 & 3 \end{pmatrix} \) then the sum of all the elements of \( P^{-1}AP \) is
- If the system of equations \( kx + y + z = k - 1 \), \( x + ky + z = k - 1 \), and \( x + y + kz = k - 1 \) has infinite solutions, then \( k \) is
- The value of the integral \( \int_C (2xy - x^2) \, dx + (x^2 + y^2) \, dy \) where \( C \) is the boundary of the region enclosed by \( y = x^2 \) and \( y^2 = x \), described in the positive sense, is
- Let \( f(x) = \log x \). The number \( C \) strictly between \( e^2 \) and \( e^3 \) such that its reciprocal is equal to \( \frac{f(e^3) - f(e^2)}{e^3 - e^2} \) is
- The solution of the differential equation \( (D^2 + 2)y = x^2 \) is
View More Questions