Question:
Which of the following drug binds to albumin?
Which of the following drug binds to albumin?
Show Hint
Acids $\rightarrow$ Albumin; Bases $\rightarrow$ Glycoprotein (AAG).
Updated On: May 28, 2026
- Bupivacaine
- Valproic acid
- Lidocaine
- Imipramine
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The Correct Option is B
Solution and Explanation
Step 1: Concept
Plasma protein binding significantly influences drug distribution and elimination.
Step 2: Meaning
Albumin typically binds to acidic and neutral drugs, while alpha-1 acid glycoprotein binds to basic drugs.
Step 3: Analysis
Valproic acid (B) is an acidic drug and binds extensively to albumin. Bupivacaine (A), Lidocaine (C), and Imipramine (D) are basic drugs that primarily bind to alpha-1 acid glycoprotein.
Step 4: Conclusion
Valproic acid is the drug in this list that binds to albumin.
Final Answer: (B)
Plasma protein binding significantly influences drug distribution and elimination.
Step 2: Meaning
Albumin typically binds to acidic and neutral drugs, while alpha-1 acid glycoprotein binds to basic drugs.
Step 3: Analysis
Valproic acid (B) is an acidic drug and binds extensively to albumin. Bupivacaine (A), Lidocaine (C), and Imipramine (D) are basic drugs that primarily bind to alpha-1 acid glycoprotein.
Step 4: Conclusion
Valproic acid is the drug in this list that binds to albumin.
Final Answer: (B)
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