Question

Match List-I with List-II

List-I (Name of the lipid) & List-II (Nature of the lipid)
(A) Ceramide & (III) Structural parent of all sphingolipids
(B) Cerebroside & (IV) Neutral Glycosphingolipid
(C) Ganglioside & (II) Acidic (charged) glycosphingolipid
(D) Platelet Activating Factor & (I) Ether glycerophospholipid

• (A) - (II), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (III), (B) - (IV), (C) - (II), (D) - (I)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

Remember that Gangliosides always contain sialic acid, which makes them acidic and negatively charged. Platelet Activating Factor is a unique ether-linked phospholipid.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
Lipids are structurally diverse hydrophobic or amphipathic molecules.
Sphingolipids contain a sphingosine backbone, whereas glycerophospholipids contain a glycerol backbone.

Step 2: Detailed Explanation:
Let us match the lipids in List-I with their biochemical classifications in List-II:
- (A) Ceramide $\rightarrow$ (III) Structural parent of all sphingolipids:
A ceramide consists of a sphingosine backbone linked to a fatty acid via an amide bond.
It serves as the basic structural precursor from which all other complex sphingolipids are synthesized.
- (B) Cerebroside $\rightarrow$ (IV) Neutral Glycosphingolipid:
Cerebrosides are glycosphingolipids that have a single uncharged sugar residue (such as glucose or galactose) attached to the terminal hydroxyl group of a ceramide.
Because the sugar head group lacks a charge at physiological pH, it is classified as a neutral glycosphingolipid.
- (C) Ganglioside $\rightarrow$ (II) Acidic (charged) glycosphingolipid:
Gangliosides are complex glycosphingolipids containing an oligosaccharide head group with one or more sialic acid (N-acetylneuraminic acid) residues.
Sialic acid contains a carboxyl group that is ionized at physiological pH, imparting a negative charge to the molecule.
- (D) Platelet Activating Factor $\rightarrow$ (I) Ether glycerophospholipid:
Platelet Activating Factor (PAF) is a specialized phospholipid containing an ether linkage at the C-1 position and an acetyl ester linkage at the C-2 position of the glycerol backbone.
This makes the matching sequence: (A)-(III), (B)-(IV), (C)-(II), (D)-(I).

Step 3: Final Answer:
The correct matching sequence is (A) - (III), (B) - (IV), (C) - (II), (D) - (I).