Step 1: Concept
The ozone ($O_{3}$) layer in the stratosphere acts as a shield against harmful ultraviolet (UV) radiation from the sun.
Step 2: Meaning
When this layer is depleted, higher levels of UV-B radiation reach the earth's surface.
Step 3: Analysis
UV-B radiation is known to damage biological tissues, leading to mutations in DNA (skin cancer), damage to eye proteins (cataracts), and premature ageing of the skin.
Step 4: Conclusion
These health issues are direct consequences of ozone layer depletion.
Final Answer: (C)