Question:
A young adult presents with facial pain and painful vesicular lesions in the mouth. Tzanck smear reveals multinucleated giant cells with intranuclear inclusions. What is the most likely causative organism?
A young adult presents with facial pain and painful vesicular lesions in the mouth. Tzanck smear reveals multinucleated giant cells with intranuclear inclusions. What is the most likely causative organism?
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Painful vesicles + multinucleated giant cells on Tzanck smear = HSV.
Updated On: May 14, 2026
- Adenovirus
- Cytomegalovirus
- EBV
- HSV
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The Correct Option is D
Solution and Explanation
Concept:
Herpes simplex virus causes painful vesicular lesions. Tzanck smear shows multinucleated giant cells and intranuclear inclusions.
Step 1: Identify the lesion.
Painful oral vesicles are suggestive of herpes infection.
Step 2: Use Tzanck smear clue.
Tzanck smear showing multinucleated giant cells is classically seen in: \[ \text{HSV infection} \]
Step 3: Choose organism.
Therefore, the causative organism is: \[ \text{Herpes simplex virus} \]
Step 1: Identify the lesion.
Painful oral vesicles are suggestive of herpes infection.
Step 2: Use Tzanck smear clue.
Tzanck smear showing multinucleated giant cells is classically seen in: \[ \text{HSV infection} \]
Step 3: Choose organism.
Therefore, the causative organism is: \[ \text{Herpes simplex virus} \]
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